Excellent Science INNOVATION
improved method for depositing micro volumes of sample solution into serial stacks
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Market Maturity: Tech Ready
These are innovations that are progressing on technology development process (e.g. pilots, prototypes, demonstration). Learn more
Market Creation Potential
This innovation was assessed by the JRC’s Market Creation Potential indicator framework as addressing the needs of existing markets and existing customers. Learn more
Women-led innovation
A woman had a leadership role in developing this innovation in at least one of the Key Innovator organisations listed below.
Go to Market needs
Needs that, if addressed, can increase the chances this innovation gets to (or closer to) the market incude:
  • Prepare for Market entry
  • Secure capital
  • Scale-up market opportunities
Location of Key Innovators developing this innovation
Key Innovators
CONSIGLIO NAZIONALE DELLE RICERCHE
ROMA, IT
Higher Education Institute / Research Centre
UNIVERSITAT LINZ
LINZ, AT
Higher Education Institute / Research Centre
GINOLIS OY
OULUNSALO, FI
Small or Medium Enterprise
UN Sustainable Development Goals(SDG)
This innovation contributes to the following SDG(s)
SUSTAINABLE DEVELOPMENT GOAL 9
Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation

The UN explains: "Investments in infrastructure – transport, irrigation, energy and information and communication technology – are crucial to achieving sustainable development and empowering communities in many countries. It has long been recognized that growth in productivity and incomes, and improvements in health and education outcomes require investment in infrastructure."

SUSTAINABLE DEVELOPMENT GOAL 3
Ensure healthy lives and promote well-being for all at all ages

The UN explains: "Significant strides have been made in increasing life expectancy and reducing some of the common killers responsible for child and maternal mortality.

Major progress has also been made on increasing access to clean water and sanitation, reducing malaria, tuberculosis, polio and the spread of HIV/AIDS.

However, many more efforts are needed to control a wide range of diseases and address many different persistent and emerging health issues."

The EU-funded Research Project
This innovation was developed under the Horizon 2020 project SensApp with an end date of 31/12/2021
Description of Project SensApp
The detection of biomarkers in body fluids is of great importance for disease early diagnosis. The clinical practice uses typically immunoassay methods (e.g. ELISA, Enzyme-Linked Immuno Sorbent Assay, and related techniques) for biomarker determination. Unfortunately, these techniques fail dramatically in a wide variety of cases where the concentration of biomarkers falls below the limit of detection (LOD). The Alzheimer’s disease (AD) is one real example. Nowadays the AD diagnosis from blood collection is not possible just for the above-mentioned reason. The AD biomarkers are low abundant in blood and they can be determined only in cerebrospinal fluid (CSF), thus requiring a highly invasive intervention on the patient (lumbar puncture) under hospitalization, causing also high costs for the public health. SensApp seeks to develop a bench-top “super-sensor” able to determine low abundant AD biomarkers simply in plasma, from peripheral blood, for very early and non-invasive diagnosis in routine clinical practice. We will develop an outstanding innovative technology that we call droplet split-and-stack (DSS), able to stack the biomarker molecules in sub-microlitre volumes on a solid support before the immunoreactions, thus avoiding diffusion limits and improving significantly the LOD. The super-sensor will be fully automated and cost-effective. An integrated micro-system in polar materials will split the mother drop of the plasma sample in tiny droplets through electric fields and will accumulate them on a microscale site, while an innovative integrated optical system will detect the fluorescence signal directly on the reaction support. SensApp will lay the foundations for a future European industrial leadership involved in all of those clinical studies where the detection of low abundant biomarkers is of vital importance for the welfare of society.

Innnovation Radar's analysis of this innovation is based on data collected on 22/02/2020.